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Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve CD45RA+ Regulatory T Cell in Chronic Heart Failure
Joint Authors
Ma, Yan-hui
Zhou, Yun-lan
Yue, Chao-yan
Zhang, Guang-hui
Deng, Lin
Xie, Guo-hua
Xu, Wei-ping
Shen, Li-song
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-23
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The effect of vitamin D pertinent to cardiovascular health on the heart itself is considered to shift toward an anti-inflammatory response in chronic heart failure (CHF); however, its underlying mechanism is not completely understood.
In this study, we demonstrated that plasma 25(OH)D level, negatively associated with NT-ProBNP, correlated with the decreased Treg in CHF compared to the patients with other cardiovascular diseases and healthy and older donors.
Naïve Treg cell (CD4+CD45RA+Foxp3loT) subset, rather than whole Treg cells, contributes to the reduction of Treg in CHF.
1,25(OH)2D treatment maintained partial expression of CD45RA on CD4+T cell after αCD3/CD28 monoclonal antibodies activation and ameliorated the impaired CD4+CD45RA+T cell function from CHF patients through upregulating Foxp3 expression and IL-10 secretion in vitro.
Low level of vitamin D receptor (VDR) was detected in CD4+CD45RA+T cell of CHF than control, while 1,25(OH)2D treatment increased the VDR expression to exert its immunosuppression on T cell.
The results of this study might provide tangible evidence to our knowledge of the impact of vitamin D supplementation on naïve Tregs, which may offer new means of preventing and treating CHF.
American Psychological Association (APA)
Ma, Yan-hui& Zhou, Yun-lan& Yue, Chao-yan& Zhang, Guang-hui& Deng, Lin& Xie, Guo-hua…[et al.]. 2015. Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve CD45RA+ Regulatory T Cell in Chronic Heart Failure. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1068518
Modern Language Association (MLA)
Ma, Yan-hui…[et al.]. Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve CD45RA+ Regulatory T Cell in Chronic Heart Failure. Journal of Immunology Research No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1068518
American Medical Association (AMA)
Ma, Yan-hui& Zhou, Yun-lan& Yue, Chao-yan& Zhang, Guang-hui& Deng, Lin& Xie, Guo-hua…[et al.]. Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve CD45RA+ Regulatory T Cell in Chronic Heart Failure. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1068518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068518