Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome
Joint Authors
Rojas-Villarraga, Adriana
Castiblanco, John
Sarmiento-Monroy, Juan Camilo
Mantilla, Ruben Dario
Anaya, Juan-Manuel
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Studies documenting increased risk of developing autoimmune diseases (ADs) have shown that these conditions share several immunogenetic mechanisms (i.e., the autoimmune tautology).
This report explored familial aggregation and segregation of AD, polyautoimmunity, and multiple autoimmune syndrome (MAS) in 210 families.
Familial aggregation was examined for first-degree relatives.
Segregation analysis was implemented as in S.A.G.E.
release 6.3.
Data showed differences between late- and early-onset families regarding their age, age of onset, and sex.
Familial aggregation of AD in late- and early-onset families was observed.
For polyautoimmunity as a trait, only aggregation was observed between sibling pairs in late-onset families.
No aggregation was observed for MAS.
Segregation analyses for AD suggested major gene(s) with no clear discernible classical known Mendelian transmission in late-onset families, while for polyautoimmunity and MAS no model was implied.
Data suggest that polyautoimmunity and MAS are not independent traits and that gender, age, and age of onset are interrelated factors influencing autoimmunity.
American Psychological Association (APA)
Castiblanco, John& Sarmiento-Monroy, Juan Camilo& Mantilla, Ruben Dario& Rojas-Villarraga, Adriana& Anaya, Juan-Manuel. 2015. Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068523
Modern Language Association (MLA)
Castiblanco, John…[et al.]. Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068523
American Medical Association (AMA)
Castiblanco, John& Sarmiento-Monroy, Juan Camilo& Mantilla, Ruben Dario& Rojas-Villarraga, Adriana& Anaya, Juan-Manuel. Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068523