Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205
Joint Authors
Costa, Valerio
D'Apice, Luciana
Aprile, M.
Trovato, Maria
De Berardinis, Piergiuseppe
Sartorius, Rossella
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The filamentous bacteriophage fd, codisplaying antigenic determinants and a single chain antibody fragment directed against the dendritic cell receptor DEC-205, is a promising vaccine candidate for its safety and its ability to elicit innate and adaptive immune response in absence of adjuvants.
By using a system vaccinology approach based on RNA-Sequencing (RNA-Seq) analysis, we describe a relevant gene modulation in dendritic cells pulsed with anti-DEC-205 bacteriophages fd.
RNA-Seq data analysis indicates that the bacteriophage fd virions are sensed as a pathogen by dendritic cells; they activate the danger receptors that trigger an innate immune response and thus confer a strong adjuvanticity that is needed to obtain a long-lasting adaptive immune response.
American Psychological Association (APA)
D'Apice, Luciana& Costa, Valerio& Sartorius, Rossella& Trovato, Maria& Aprile, M.& De Berardinis, Piergiuseppe. 2015. Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068525
Modern Language Association (MLA)
D'Apice, Luciana…[et al.]. Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068525
American Medical Association (AMA)
D'Apice, Luciana& Costa, Valerio& Sartorius, Rossella& Trovato, Maria& Aprile, M.& De Berardinis, Piergiuseppe. Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068525