Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination
Joint Authors
Vormehr, Mathias
Schrörs, Barbara
Boegel, Sebastian
Löwer, Martin
Türeci, Özlem
Sahin, Ugur
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Advances in nucleic acid sequencing technologies have revolutionized the field of genomics, allowing the efficient targeting of mutated neoantigens for personalized cancer vaccination.
Due to their absence during negative selection of T cells and their lack of expression in healthy tissue, tumor mutations are considered as optimal targets for cancer immunotherapy.
Preclinical and early clinical data suggest that synthetic mRNA can serve as potent drug format allowing the cost efficient production of highly efficient vaccines in a timely manner.
In this review, we describe a process, which integrates next generation sequencing based cancer mutanome mapping, in silico target selection and prioritization approaches, and mRNA vaccine manufacturing and delivery into a process we refer to as MERIT (mutanome engineered RNA immunotherapy).
American Psychological Association (APA)
Vormehr, Mathias& Schrörs, Barbara& Boegel, Sebastian& Löwer, Martin& Türeci, Özlem& Sahin, Ugur. 2015. Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068528
Modern Language Association (MLA)
Vormehr, Mathias…[et al.]. Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068528
American Medical Association (AMA)
Vormehr, Mathias& Schrörs, Barbara& Boegel, Sebastian& Löwer, Martin& Türeci, Özlem& Sahin, Ugur. Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068528