Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection
Joint Authors
Chiuso-Minicucci, Fernanda
Zorzella-Pezavento, Sofia Fernanda Gonçalves
Fraga-Silva, Thais F. C.
Mimura, Luiza A. N.
Marchetti, Camila M.
Venturini, James
Arruda, Maria S. P.
França, Thais Graziela Donegá
Sartori, Alexandrina
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Multiple sclerosis (MS) is an inflammatory/autoimmune disease of the central nervous system (CNS) mainly mediated by myelin specific T cells.
It is widely believed that environmental factors, including fungal infections, contribute to disease induction or evolution.
Even though Candida infection among MS patients has been described, the participation of this fungus in this pathology is not clear.
The purpose of this work was to evaluate the effect of a Candida albicans infection on experimental autoimmune encephalomyelitis (EAE) that is a widely accepted model to study MS.
Female C57BL/6 mice were infected with C.
albicans and 3 days later, animals were submitted to EAE induction by immunization with myelin oligodendrocyte glycoprotein.
Previous infection increased the clinical score and also the body weight loss.
EAE aggravation was associated with expansion of peripheral CD4+ T cells and production of high levels of TNF-α, IFN-γ IL-6, and IL-17 by spleen and CNS cells.
In addition to yeast and hyphae, fungus specific T cells were found in the CNS.
These findings suggest that C.
albicans infection before EAE induction aggravates EAE, and possibly MS, mainly by CNS dissemination and local induction of encephalitogenic cytokines.
Peripheral production of encephalitogenic cytokines could also contribute to disease aggravation.
American Psychological Association (APA)
Fraga-Silva, Thais F. C.& Mimura, Luiza A. N.& Marchetti, Camila M.& Chiuso-Minicucci, Fernanda& França, Thais Graziela Donegá& Zorzella-Pezavento, Sofia Fernanda Gonçalves…[et al.]. 2015. Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068538
Modern Language Association (MLA)
Fraga-Silva, Thais F. C.…[et al.]. Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068538
American Medical Association (AMA)
Fraga-Silva, Thais F. C.& Mimura, Luiza A. N.& Marchetti, Camila M.& Chiuso-Minicucci, Fernanda& França, Thais Graziela Donegá& Zorzella-Pezavento, Sofia Fernanda Gonçalves…[et al.]. Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068538