Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes
Joint Authors
de Oliveira, Léa Campos
Goldberg, Anna Carla
Marin, Maria Lucia Carnevale
Schneidwind, Karina Rosa
Frade, Amanda Farage
Kalil, Jorge
Miura, Irene Kasue
Pugliese, Renata Pereira Sustovich
Danesi, Vera Lucia Baggio
Porta, Gilda
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pediatric autoimmune hepatitis (AIH) patients present hypergammaglobulinemia, periportal CD8+ cytotoxic T cell infiltration, and cirrhosis.
Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1.
We previously detected increased IgE serum levels and sought to compare clinical and histological features according to IgE levels in AIH ( n = 74 , ages 1–14 years) patients.
Additionally, we typed 117 patients and 227 controls for functional polymorphisms of IL4, IL13, IL5, and IL4RA genes involved in IgE switching and eosinophil maturation that might contribute to overall genetic susceptibility to AIH.
Serum IgE levels were high in 55% of AIH-1, but only in 12% of AIH-2 ( P = 0.003 ) patients.
Liver IgE was present in 91.3% of AIH-1 patients.
The A alleles at both IL13 rs20541 and IL4RA rs1805011 were associated with AIH-1 ( P = 0.024 , OR = 1.55 and P < 0.0001 , OR = 2.15, resp.).
Furthermore, individuals presenting homozygosis for the A allele at IL4RA rs1805011 and HLA-DRB1 03 ∗ and/or 13 ∗ allele had sixfold greater risk to develop the disease (OR = 14.00, P < 0.001 ).
The novel association suggests an additional role for IgE-linked immune response genes in the pathogenesis of AIH.
American Psychological Association (APA)
de Oliveira, Léa Campos& Goldberg, Anna Carla& Marin, Maria Lucia Carnevale& Schneidwind, Karina Rosa& Frade, Amanda Farage& Kalil, Jorge…[et al.]. 2015. Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068549
Modern Language Association (MLA)
de Oliveira, Léa Campos…[et al.]. Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068549
American Medical Association (AMA)
de Oliveira, Léa Campos& Goldberg, Anna Carla& Marin, Maria Lucia Carnevale& Schneidwind, Karina Rosa& Frade, Amanda Farage& Kalil, Jorge…[et al.]. Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068549