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IL-21: A Pleiotropic Cytokine with Potential Applications in Oncology
Joint Authors
Croce, Michela
Ferrini, Silvano
Rigo, Valentina
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Interleukin- (IL-) 21 is a pleiotropic cytokine that regulates the activity of both innate and specific immunity.
Indeed, it costimulates T and natural killer (NK) cell proliferation and function and regulates B cell survival and differentiation and the function of dendritic cells.
In addition, IL-21 exerts divergent effects on different lymphoid cell leukemia and lymphomas, as it may support cell proliferation or on the contrary induce growth arrest or apoptosis of the neoplastic lymphoid cells.
Several preclinical studies showed that IL-21 has antitumor activity in different tumor models, through mechanism involving the activation of NK and T or B cell responses.
Moreover, IL-21’s antitumor activity can be potentiated by its combination with other immune-enhancing molecules, monoclonal antibodies recognizing tumor antigens, chemotherapy, or molecular targeted agents.
Clinical phase I-II studies of IL-21 in cancer patients showed immune stimulatory properties, acceptable toxicity profile, and antitumor effects in a fraction of patients.
In view of its tolerability, IL-21 is also suitable for combinational therapeutic regimens with other agents.
This review will summarize the biological functions of IL-21, and address its role in lymphoid malignancies and preclinical and clinical studies of cancer immunotherapy.
American Psychological Association (APA)
Croce, Michela& Rigo, Valentina& Ferrini, Silvano. 2015. IL-21: A Pleiotropic Cytokine with Potential Applications in Oncology. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068553
Modern Language Association (MLA)
Croce, Michela…[et al.]. IL-21: A Pleiotropic Cytokine with Potential Applications in Oncology. Journal of Immunology Research No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1068553
American Medical Association (AMA)
Croce, Michela& Rigo, Valentina& Ferrini, Silvano. IL-21: A Pleiotropic Cytokine with Potential Applications in Oncology. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1068553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068553