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Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease
Joint Authors
Hasan, Md. Samiul
Bergmeier, Lesley Ann
Petrushkin, Harry
Fortune, Farida
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Behçet’s disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis.
The disease follows a relapsing-remitting course and its pathogenesis is unknown.
Genetic predisposition and immune-dysregulation involving gamma delta (γδ) T cells are reported to have a role.
γδ T cells are atypical T cells, which represent a small proportion of total lymphocytes.
They have features of both innate and adaptive immunity and express characteristics of conventional T cells, natural killer cells, and myeloid antigen presenting cells.
These unconventional T cells are found in the inflammatory BD lesions and have been suggested to be responsible for inducing and/or maintaining the proinflammatory environment characteristic of the disease.
Over the last 20 years there has been much interest in the role of γδ T cells in BD.
We review the literature and discuss the roles that γδ T cells may play in BD pathogenesis.
American Psychological Association (APA)
Hasan, Md. Samiul& Bergmeier, Lesley Ann& Petrushkin, Harry& Fortune, Farida. 2015. Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068555
Modern Language Association (MLA)
Hasan, Md. Samiul…[et al.]. Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease. Journal of Immunology Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068555
American Medical Association (AMA)
Hasan, Md. Samiul& Bergmeier, Lesley Ann& Petrushkin, Harry& Fortune, Farida. Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068555