Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt
Joint Authors
Bettencourt, Bruno F.
Santos, Maria José
Costa, José António
Melo Gomes, José António
Branco, Jaime Cunha
Canhão, Helena
Mourão, Ana Filipa
Mendonça, Sílvia
Oliveira-Ramos, Filipa
Salgado, Manuel
Estanqueiro, Paula
Martins, Fernando
Lopes, Ana
Furtado, Carolina
Figueira, Ricardo
Brito, Iva
Fonseca, Joao Eurico
Bruges Armas, J.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
This study aimed to assess the genetic determinants of poor outcome in Portuguese patients with juvenile idiopathic arthritis (JIA).
Methods.
Our study was conducted in Reuma.pt, the Rheumatic Diseases Portuguese Register, which includes patients with JIA.
We collected prospectively patient and disease characteristics and a blood sample for DNA analysis.
Poor prognosis was defined as CHAQ/HAQ >0.75 at the last visit and/or the treatment with biological therapy.
A selected panel of single nucleotide polymorphisms (SNPs) associated with susceptibility was studied to verify if there was association with poor prognosis.
Results.
Of the 812 patients with JIA registered in Reuma.pt, 267 had a blood sample and registered information used to define “poor prognosis.” In univariate analysis, we found significant associations with poor prognosis for allele A of TNFA1P3/20 rs6920220, allele G of TRAF1/C5 rs3761847, and allele G of PTPN2 rs7234029.
In multivariate models, the associations with TRAF1/C5 (1.96 [1.17–3.3]) remained significant at the 5% level, while TNFA1P3/20 and PTPN2 were no longer significant.
Nevertheless, none of associations found was significant after the Bonferroni correction was applied.
Conclusion.
Our study does not confirm the association between a panel of selected SNP and poor prognosis in Portuguese patients with JIA.
American Psychological Association (APA)
Mourão, Ana Filipa& Santos, Maria José& Mendonça, Sílvia& Oliveira-Ramos, Filipa& Salgado, Manuel& Estanqueiro, Paula…[et al.]. 2015. Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068558
Modern Language Association (MLA)
Mourão, Ana Filipa…[et al.]. Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068558
American Medical Association (AMA)
Mourão, Ana Filipa& Santos, Maria José& Mendonça, Sílvia& Oliveira-Ramos, Filipa& Salgado, Manuel& Estanqueiro, Paula…[et al.]. Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068558
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068558