Estimation of the Impact of Meningococcal Serogroup C Universal Vaccination in Italy and Suggestions for the Multicomponent Serogroup B Vaccine Introduction
Joint Authors
Fortunato, Francesca
Martinelli, Domenico
Prato, Rosa
Cappelli, Maria Giovanna
Cozza, Vanessa
Chironna, Maria
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In Italy, the meningococcal C conjugate vaccine (MenC) has been offered in most regions since 2009-2010.
The incidence of Invasive Meningococcal Disease (IMD) was 0.25 confirmed cases per 100,000 in 2011, but this may be considerably underestimated due to underdetection and underreporting.
This study estimates the impact of the MenC universal vaccination (URV) in the Puglia region by assessing the completeness of three registration sources (notifications, hospitalizations, and laboratory surveillance).
Capture-recapture analysis was performed on meningococcal meningitis collected within 2001–2013.
The impact of URV among ≤18-year-olds was assessed by attributable benefit, preventable fraction, and prevented fraction.
Missed opportunities for vaccination were evaluated from surveillance of IMD.
The proportion of detected serogroups was applied to the number of IMD in the postvaccination period to compute the cases still preventable.
The sensitivity of the three sources was 36.7% (95% CI: 17.5%–57.9%) and registrations lost nearly 28 cases/year in the period.
Attributable benefit of URV was −0.5 cases per 100,000, preventable fraction 19.6%, and prevented fraction 31.3%.
Three adolescent cases missed the opportunity to be vaccinated.
The multicomponent serogroup B meningococcal vaccine has the potential to further prevent at least three other cases/year.
Vaccination strategy against serogroup B together with existing programmes makes IMD a 100% vaccine-preventable disease.
American Psychological Association (APA)
Martinelli, Domenico& Fortunato, Francesca& Cappelli, Maria Giovanna& Cozza, Vanessa& Chironna, Maria& Prato, Rosa. 2015. Estimation of the Impact of Meningococcal Serogroup C Universal Vaccination in Italy and Suggestions for the Multicomponent Serogroup B Vaccine Introduction. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068559
Modern Language Association (MLA)
Martinelli, Domenico…[et al.]. Estimation of the Impact of Meningococcal Serogroup C Universal Vaccination in Italy and Suggestions for the Multicomponent Serogroup B Vaccine Introduction. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068559
American Medical Association (AMA)
Martinelli, Domenico& Fortunato, Francesca& Cappelli, Maria Giovanna& Cozza, Vanessa& Chironna, Maria& Prato, Rosa. Estimation of the Impact of Meningococcal Serogroup C Universal Vaccination in Italy and Suggestions for the Multicomponent Serogroup B Vaccine Introduction. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068559