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Computational Modelling Approaches on Epigenetic Factors in Neurodegenerative and Autoimmune Diseases and Their Mechanistic Analysis
Joint Authors
Khanam Irin, Afroza
Tom Kodamullil, Alpha
Gündel, Michaela
Hofmann-Apitius, Martin
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neurodegenerative as well as autoimmune diseases have unclear aetiologies, but an increasing number of evidences report for a combination of genetic and epigenetic alterations that predispose for the development of disease.
This review examines the major milestones in epigenetics research in the context of diseases and various computational approaches developed in the last decades to unravel new epigenetic modifications.
However, there are limited studies that systematically link genetic and epigenetic alterations of DNA to the aetiology of diseases.
In this work, we demonstrate how disease-related epigenetic knowledge can be systematically captured and integrated with heterogeneous information into a functional context using Biological Expression Language (BEL).
This novel methodology, based on BEL, enables us to integrate epigenetic modifications such as DNA methylation or acetylation of histones into a specific disease network.
As an example, we depict the integration of epigenetic and genetic factors in a functional context specific to Parkinson’s disease (PD) and Multiple Sclerosis (MS).
American Psychological Association (APA)
Khanam Irin, Afroza& Tom Kodamullil, Alpha& Gündel, Michaela& Hofmann-Apitius, Martin. 2015. Computational Modelling Approaches on Epigenetic Factors in Neurodegenerative and Autoimmune Diseases and Their Mechanistic Analysis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068569
Modern Language Association (MLA)
Khanam Irin, Afroza…[et al.]. Computational Modelling Approaches on Epigenetic Factors in Neurodegenerative and Autoimmune Diseases and Their Mechanistic Analysis. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068569
American Medical Association (AMA)
Khanam Irin, Afroza& Tom Kodamullil, Alpha& Gündel, Michaela& Hofmann-Apitius, Martin. Computational Modelling Approaches on Epigenetic Factors in Neurodegenerative and Autoimmune Diseases and Their Mechanistic Analysis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068569