EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses
Joint Authors
Lafuente, Esther M.
Flower, Darren R.
Glutting, John-Paul
Reche, Pedro A.
Molero-Abraham, Magdalena
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Concerns that variola viruses might be used as bioweapons have renewed the interest indeveloping new and safer smallpox vaccines.
Variola virus genomes are now widely available, allowing computational characterization of the entire T-cell epitome and the use of such information to develop safe and yet effective vaccines.
To this end, we identified 124 proteins shared between various species of pathogenic orthopoxviruses including variola minor and major, monkeypox, cowpox, and vaccinia viruses, and we targeted them for T-cell epitope prediction.
We recognized 8,106, and 8,483 unique class I and class II MHC-restricted T-cell epitopes that are shared by all mentioned orthopoxviruses.
Subsequently, we developed an immunological resource, EPIPOX, upon the predicted T-cell epitome.
EPIPOX is freely available online and it has been designed to facilitate reverse vaccinology.
Thus, EPIPOX includes key epitope-focused protein annotations: time point expression, presence of leader and transmembrane signals, and known location on outer membrane structures of the infective viruses.
These features can be used to select specific T-cell epitopes suitable for experimental validation restricted by single MHC alleles, as combinations thereof, or by MHC supertypes.
American Psychological Association (APA)
Molero-Abraham, Magdalena& Glutting, John-Paul& Flower, Darren R.& Lafuente, Esther M.& Reche, Pedro A.. 2015. EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068570
Modern Language Association (MLA)
Molero-Abraham, Magdalena…[et al.]. EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068570
American Medical Association (AMA)
Molero-Abraham, Magdalena& Glutting, John-Paul& Flower, Darren R.& Lafuente, Esther M.& Reche, Pedro A.. EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068570