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Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models
Joint Authors
Bocharov, Gennady
Argilaguet, Jordi
Meyerhans, Andreas
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Virus infections represent complex biological systems governed by multiple-level regulatory processes of virus replication and host immune responses.
Understanding of the infection means an ability to predict the systems behaviour under various conditions.
Such predictions can only rely upon quantitative mathematical models.
The model formulations should be tightly linked to a fundamental step called “coordinatization” (Hermann Weyl), that is, the definition of observables, parameters, and structures that enable the link with a biological phenotype.
In this review, we analyse the mathematical modelling approaches to LCMV infection in mice that resulted in quantification of some fundamental parameters of the CTL-mediated virus control including the rates of T cell turnover, infected target cell elimination, and precursor frequencies.
We show how the modelling approaches can be implemented to address diverse aspects of immune system functioning under normal conditions and in response to LCMV and, importantly, make quantitative predictions of the outcomes of immune system perturbations.
This may highlight the notion that data-driven applications of meaningful mathematical models in infection biology remain a challenge.
American Psychological Association (APA)
Bocharov, Gennady& Argilaguet, Jordi& Meyerhans, Andreas. 2015. Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068573
Modern Language Association (MLA)
Bocharov, Gennady…[et al.]. Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068573
American Medical Association (AMA)
Bocharov, Gennady& Argilaguet, Jordi& Meyerhans, Andreas. Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068573