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IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation
Joint Authors
Piccin, Ottavio
Righi, Simona
Piccaluga, Pier Paolo
Landolfo, Santo
Fuligni, Fabio
Agostinelli, Claudio
Tripodo, Claudio
Re, Maria Carla
Clò, Alberto
Miserocchi, Anna
Morini, Silvia
Gariglio, Marisa
Rinaldi-Ceroni, Alberto
De Andrea, Marco
Pileri, Stefano A.
Gibellini, Davide
Ferri, G. G.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-22
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation.
In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation of B- and T-cells.
We explored the role of IFI16 in normal B-cell subsets by analysing its expression and relationship with the major transcription factors involved in germinal center (GC) development and plasma-cell (PC) maturation.
IFI16 mRNA was differentially expressed in B-cell subsets with significant decrease in IFI16 mRNA in GC and PCs with respect to naïve and memory subsets.
IFI16 mRNA expression is inversely correlated with a few master regulators of B-cell differentiation such as BCL6, XBP1, POU2AF1, and BLIMP1.
In contrast, IFI16 expression positively correlated with STAT3, REL, SPIB, RELA, RELB, IRF4, STAT5B, and STAT5A.
ARACNE algorithm indicated a direct regulation of IFI16 by BCL6, STAT5B, and RELB, whereas the relationship between IFI16 and the other factors is modulated by intermediate factors.
In addition, analysis of the CD40 signaling pathway showed that IFI16 gene expression directly correlated with NF-κB activation, indicating that IFI16 could be considered an upstream modulator of NF-κB in human B-cells.
American Psychological Association (APA)
Piccaluga, Pier Paolo& Agostinelli, Claudio& Fuligni, Fabio& Righi, Simona& Tripodo, Claudio& Re, Maria Carla…[et al.]. 2015. IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1068582
Modern Language Association (MLA)
Piccaluga, Pier Paolo…[et al.]. IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation. Journal of Immunology Research No. 2015 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1068582
American Medical Association (AMA)
Piccaluga, Pier Paolo& Agostinelli, Claudio& Fuligni, Fabio& Righi, Simona& Tripodo, Claudio& Re, Maria Carla…[et al.]. IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1068582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068582