Interactions between MSCs and Immune Cells: Implications for Bone Healing
Joint Authors
Cui, Quanjun
Dighe, Abhijit S.
Kovach, Tracy K.
Lobo, Peter I.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
It is estimated that, of the 7.9 million fractures sustained in the United States each year, 5% to 20% result in delayed or impaired healing requiring therapeutic intervention.
Following fracture injury, there is an initial inflammatory response that plays a crucial role in bone healing; however, prolonged inflammation is inhibitory for fracture repair.
The precise spatial and temporal impact of immune cells and their cytokines on fracture healing remains obscure.
Some cytokines are reported to be proosteogenic while others inhibit bone healing.
Cell-based therapy utilizing mesenchymal stromal cells (MSCs) is an attractive option for augmenting the fracture repair process.
Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms.
In this paper, we review the current literature on both in vitro and in vivo studies on the role of the immune system in fracture repair, the use of MSCs in the enhancement of fracture healing, and interactions between MSCs and immune cells.
Insight into this paradigm can provide valuable clues in identifying cellular and noncellular targets that can potentially be modulated to enhance both natural bone healing and bone repair augmented by the exogenous addition of MSCs.
American Psychological Association (APA)
Kovach, Tracy K.& Dighe, Abhijit S.& Lobo, Peter I.& Cui, Quanjun. 2015. Interactions between MSCs and Immune Cells: Implications for Bone Healing. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1068584
Modern Language Association (MLA)
Kovach, Tracy K.…[et al.]. Interactions between MSCs and Immune Cells: Implications for Bone Healing. Journal of Immunology Research No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1068584
American Medical Association (AMA)
Kovach, Tracy K.& Dighe, Abhijit S.& Lobo, Peter I.& Cui, Quanjun. Interactions between MSCs and Immune Cells: Implications for Bone Healing. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1068584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068584