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Increased NY-ESO-1 Expression and Reduced Infiltrating CD3+ T Cells in Cutaneous Melanoma
Joint Authors
Giavina-Bianchi, Pedro
Giavina-Bianchi, Mara
Sotto, Mirian Nacagami
Muzikansky, Alona
Festa-Neto, Cyro
Duncan, Lyn M.
Kalil, Jorge
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy.
NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma.
NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79), rarely in in situ melanoma (1/10) and not in benign nevi (0/20).
Marked intratumoral heterogeneity of NY-ESO-1 protein expression was observed.
NY-ESO-1 expression was associated with increased primary tumor thickness ( P = 0.007 ) and inversely correlated with superficial spreading melanoma ( P < 0.02 ).
NY-ESO-1 expression was also associated with reduced numbers and density of CD3+ tumor infiltrating lymphocytes ( P = 0.017 ).
When NY-ESO-1 protein was expressed, CD3+ T cells were less diffusely infiltrating the tumor and were more often arranged in small clusters ( P = 0.010 ) or as isolated cells ( P = 0.002 ) than in large clusters of more than five lymphocytes.
No correlation of NY-ESO-1 expression with gender, age, tumor site, ulceration, lymph node sentinel status, or survival was observed.
NY-ESO-1 expression in melanoma was associated with tumor progression, including increased tumor thickness, and with reduced tumor infiltrating lymphocytes.
American Psychological Association (APA)
Giavina-Bianchi, Mara& Giavina-Bianchi, Pedro& Sotto, Mirian Nacagami& Muzikansky, Alona& Kalil, Jorge& Festa-Neto, Cyro…[et al.]. 2015. Increased NY-ESO-1 Expression and Reduced Infiltrating CD3+ T Cells in Cutaneous Melanoma. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068588
Modern Language Association (MLA)
Giavina-Bianchi, Mara…[et al.]. Increased NY-ESO-1 Expression and Reduced Infiltrating CD3+ T Cells in Cutaneous Melanoma. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068588
American Medical Association (AMA)
Giavina-Bianchi, Mara& Giavina-Bianchi, Pedro& Sotto, Mirian Nacagami& Muzikansky, Alona& Kalil, Jorge& Festa-Neto, Cyro…[et al.]. Increased NY-ESO-1 Expression and Reduced Infiltrating CD3+ T Cells in Cutaneous Melanoma. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068588