Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis
Joint Authors
Sakhno, Ludmila V.
Chernykh, Elena R.
Nikonov, Sergey D.
Shevela, Ekaterina Ya.
Ostanin, Alexander A.
Tikhonova, Marina A.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated in vitro macrophages and dendritic cells, were investigated in the patients with pulmonary tuberculosis (TB) differing in lymphocyte reactivity to M.
tuberculosis antigens (PPD-reactive versus PPD-anergic patients).
We revealed the distinct impairments in patient APC functions.
For example, the monocyte dysfunctions were displayed by low CD86 and HLA-DR expression, 2-fold increase in CD14+CD16+ expression, the high numbers of IL-10-producing cells, and enhanced IL-10 and IL-6 production upon LPS-stimulation.
The macrophages which were in vitro generated from peripheral blood monocytes under GM-CSF were characterized by Th1/Th2-balance shifting (downproduction of IFN-γ coupled with upproduction of IL-10) and by reducing of allostimulatory activity in mixed lymphocyte culture.
The dendritic cells (generated in vitro from peripheral blood monocytes upon GM-CSF + IFN-α) were characterized by impaired maturation/activation, a lower level of IFN-γ production in conjunction with an enhanced capacity to produce IL-10 and IL-6, and a profound reduction of allostimulatory activity.
The APC dysfunctions were found to be most prominent in PPD-anergic patients.
The possible role of APC impairments in reducing the antigen-specific T-cell response to M.
tuberculosis was discussed.
American Psychological Association (APA)
Sakhno, Ludmila V.& Shevela, Ekaterina Ya.& Tikhonova, Marina A.& Nikonov, Sergey D.& Ostanin, Alexander A.& Chernykh, Elena R.. 2015. Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1068597
Modern Language Association (MLA)
Sakhno, Ludmila V.…[et al.]. Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis. Journal of Immunology Research No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1068597
American Medical Association (AMA)
Sakhno, Ludmila V.& Shevela, Ekaterina Ya.& Tikhonova, Marina A.& Nikonov, Sergey D.& Ostanin, Alexander A.& Chernykh, Elena R.. Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1068597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068597