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RNA-Based Vaccines in Cancer Immunotherapy
Joint Authors
Nair, Smita K.
McNamara, Megan A.
Holl, Eda K.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
RNA vaccines traditionally consist of messenger RNA synthesized by in vitro transcription using a bacteriophage RNA polymerase and template DNA that encodes the antigen(s) of interest.
Once administered and internalized by host cells, the mRNA transcripts are translated directly in the cytoplasm and then the resulting antigens are presented to antigen presenting cells to stimulate an immune response.
Alternatively, dendritic cells can be loaded with either tumor associated antigen mRNA or total tumor RNA and delivered to the host to elicit a specific immune response.
In this review, we will explain why RNA vaccines represent an attractive platform for cancer immunotherapy, discuss modifications to RNA structure that have been developed to optimize mRNA vaccine stability and translational efficiency, and describe strategies for nonviral delivery of mRNA vaccines, highlighting key preclinical and clinical data related to cancer immunotherapy.
American Psychological Association (APA)
McNamara, Megan A.& Nair, Smita K.& Holl, Eda K.. 2015. RNA-Based Vaccines in Cancer Immunotherapy. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068599
Modern Language Association (MLA)
McNamara, Megan A.…[et al.]. RNA-Based Vaccines in Cancer Immunotherapy. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068599
American Medical Association (AMA)
McNamara, Megan A.& Nair, Smita K.& Holl, Eda K.. RNA-Based Vaccines in Cancer Immunotherapy. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068599