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Chemokine Receptor Expression on Normal Blood CD56+ NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population
Joint Authors
Lima, Margarida
Leander, Magdalena
Santos, Marlene
Santos, Ana Helena
Lau, Catarina
Queirós, Maria Luís
Gonçalves, Marta
Fonseca, Sónia
Moura, João
Teixeira, Maria dos Anjos
Orfao, Alberto
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-12
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Studies of chemokine receptors (CKR) in natural killer- (NK-) cells have already been published, but only a few gave detailed information on its differential expression on blood NK-cell subsets.
We report on the expression of the inflammatory and homeostatic CKR on normal blood CD56+low CD16+ and CD56+high CD16-/+low NK-cells.
Conventional CD56+low and CD56+high NK-cells present in the normal PB do express CKR for inflammatory cytokines, although with different patterns CD56+low NK-cells are mainly CXCR1/CXCR2+ and CXCR3/CCR5−/+, whereas mostly CD56+high NK-cells are CXCR1/CXCR2− and CXCR3/CCR5+.
Both NK-cell subsets have variable CXCR4 expression and are CCR4− and CCR6−.
The CKR repertoire of the CD56+low NK-cells approaches to that of neutrophils, whereas the CKR repertoire of the CD56+high NK-cells mimics that of Th1+ T cells, suggesting that these cells are prepared to migrate into inflamed tissues at different phases of the immune response.
In addition, we describe a subpopulation of NK-cells with intermediate levels of CD56 expression, which we named CD56+int NK-cells.
These NK-cells are CXCR3/CCR5+, they have intermediate levels of expression of CD16, CD62L, CD94, and CD122, and they are CD57− and CD158a−.
In view of their phenotypic features, we hypothesize that they correspond to a transitional stage, between the well-known CD56+high and CD56+low NK-cells populations.
American Psychological Association (APA)
Lima, Margarida& Leander, Magdalena& Santos, Marlene& Santos, Ana Helena& Lau, Catarina& Queirós, Maria Luís…[et al.]. 2015. Chemokine Receptor Expression on Normal Blood CD56+ NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1068613
Modern Language Association (MLA)
Lima, Margarida…[et al.]. Chemokine Receptor Expression on Normal Blood CD56+ NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population. Journal of Immunology Research No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1068613
American Medical Association (AMA)
Lima, Margarida& Leander, Magdalena& Santos, Marlene& Santos, Ana Helena& Lau, Catarina& Queirós, Maria Luís…[et al.]. Chemokine Receptor Expression on Normal Blood CD56+ NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1068613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068613