Distribution of Peripheral Lymphocyte Populations in Primary Sjögren’s Syndrome Patients
Joint Authors
Butrimiene, Irena
Sudzius, Gintaras
Mieliauskaite, Diana
Siaurys, Almantas
Viliene, Rita
Characiejus, Dainius
Dumalakiene, Irena
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose of this study was to evaluate the lymphocyte populations’ distribution changes in peripheral blood of patients with primary Sjögren’s syndrome (pSS).
Lymphocyte populations’ distribution changes in peripheral blood of pSS patients were investigated in 52 patients with pSS and in 28 healthy controls by flow cytometry.
We found decreased absolute count of CD3+ T cell population in pSS patients.
Analysis of CD4+ T cell population showed significant proportion and absolute count differences in pSS patient’s blood with SSA/SSB antibodies (Abs) in comparison to controls.
No significant differences were observed analyzing CD4+ and CD8+ Treg subpopulation.
Proportion and absolute counts of Th17 cells were significantly lower in pSS patient’s blood.
Absolute counts of CD8+ T cells were significantly lower in pSS patients in comparison to controls and also impaired proportion and absolute counts of CD8+ subpopulations according to CD27+ and CD57+ were observed.
Absolute counts of NKT and NK cells were decreased in pSS with Abs.
B cells proportion was increased only in blood of pSS with Abs.
Lymphocyte distribution impairment can be due to genetically determined lymphopenia or lymphocyte migration from periphery to inflammatory sites or/and increased susceptibility to apoptosis.
American Psychological Association (APA)
Sudzius, Gintaras& Mieliauskaite, Diana& Siaurys, Almantas& Viliene, Rita& Butrimiene, Irena& Characiejus, Dainius…[et al.]. 2015. Distribution of Peripheral Lymphocyte Populations in Primary Sjögren’s Syndrome Patients. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068620
Modern Language Association (MLA)
Sudzius, Gintaras…[et al.]. Distribution of Peripheral Lymphocyte Populations in Primary Sjögren’s Syndrome Patients. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068620
American Medical Association (AMA)
Sudzius, Gintaras& Mieliauskaite, Diana& Siaurys, Almantas& Viliene, Rita& Butrimiene, Irena& Characiejus, Dainius…[et al.]. Distribution of Peripheral Lymphocyte Populations in Primary Sjögren’s Syndrome Patients. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068620