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Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides
Joint Authors
Ozkaya, Guven
Oral, H. Barbaros
Yazıcı, Serkan
Bülbül Başkan, Emel
Budak, Ferah
Adim, Şaduman Balaban
Ceylan Kalin, Zübeyde
Aydoğan, Kenan
Saricaoğlu, Hayriye
Tunali, Şükran
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We retrospectively analyzed the clinicopathological correlation and prognostic value of cell surface antigens expressed by peripheral blood mononuclear cells in patients with mycosis fungoides (MF).
121 consecutive MF patients were included in this study.
All patients had peripheral blood flow cytometry as part of their first visit.
TNMB and histopathological staging of the cases were retrospectively performed in accordance with International Society for Cutaneous Lymphomas/European Organization of Research and Treatment of Cancer (ISCL/EORTC) criteria at the time of flow cytometry sampling.
To determine prognostic value of cell surface antigens, cases were divided into two groups as stable and progressive disease.
17 flow cytometric analyses of 17 parapsoriasis (PP) and 11 analyses of 11 benign erythrodermic patients were included as control groups.
Fluorescent labeled monoclonal antibodies were used to detect cell surface antigens: T cells (CD3+, CD4+, CD8+, TCRαβ+, TCRγδ+, CD7+, CD4+CD7+, CD4+CD7−, and CD71+), B cells (HLA-DR+, CD19+, and HLA-DR+CD19+), NKT cells (CD3+CD16+CD56+), and NK cells (CD3−CD16+CD56+).
The mean value of all cell surface antigens was not statistically significant between parapsoriasis and MF groups.
Along with an increase in cases of MF stage statistically significant difference was found between the mean values of cell surface antigens.
Flow cytometric analysis of peripheral blood cell surface antigens in patients with mycosis fungoides may contribute to predicting disease stage and progression.
American Psychological Association (APA)
Yazıcı, Serkan& Bülbül Başkan, Emel& Budak, Ferah& Oral, H. Barbaros& Adim, Şaduman Balaban& Ceylan Kalin, Zübeyde…[et al.]. 2015. Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068622
Modern Language Association (MLA)
Yazıcı, Serkan…[et al.]. Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068622
American Medical Association (AMA)
Yazıcı, Serkan& Bülbül Başkan, Emel& Budak, Ferah& Oral, H. Barbaros& Adim, Şaduman Balaban& Ceylan Kalin, Zübeyde…[et al.]. Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068622