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The Influence and Role of Microbial Factors in Autoimmune Kidney Diseases: A Systematic Review
Joint Authors
Mayer, Gert
Kronbichler, Andreas
Kerschbaum, Julia
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
A better understanding of the pathophysiology of autoimmune disorders is desired to allow tailored interventions.
Despite increased scientific interest a direct pathogenic factor in autoimmune renal disease has been described only in a minority like membranous nephropathy or ANCA-associated vasculitis.
Nonetheless the initial step leading to the formation of these antibodies is still obscure.
In this review we will focus on the possible role of microbial factors in this context.
Staphylococcus aureus may be a direct pathogenetic factor in granulomatosis with polyangiitis (GPA).
Chronic bacterial colonization or chronic infections of the upper respiratory tract have been proposed as trigger of IgA vasculitis and IgA nephropathy.
Interventions to remove major lymphoid organs, such as tonsillectomy, have shown conflicting results but may be an option in IgA vasculitis.
Interestingly no clear clinical benefit despite similar local colonization with bacterial strains has been detected in patients with IgA nephropathy.
In systemic lupus erythematosus injection of bacterial lipopolysaccharide induced progressive lupus nephritis in mouse models.
The aim of this review is to discuss and summarize the knowledge of microbial antigens in autoimmune renal disease.
Novel methods may provide insight into the involvement of microbial antigens in the onset, progression, and prognosis of autoimmune kidney disorders.
American Psychological Association (APA)
Kronbichler, Andreas& Kerschbaum, Julia& Mayer, Gert. 2015. The Influence and Role of Microbial Factors in Autoimmune Kidney Diseases: A Systematic Review. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068624
Modern Language Association (MLA)
Kronbichler, Andreas…[et al.]. The Influence and Role of Microbial Factors in Autoimmune Kidney Diseases: A Systematic Review. Journal of Immunology Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1068624
American Medical Association (AMA)
Kronbichler, Andreas& Kerschbaum, Julia& Mayer, Gert. The Influence and Role of Microbial Factors in Autoimmune Kidney Diseases: A Systematic Review. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068624