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Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy
Joint Authors
Rona, Ortenberg
Zippel, D.
Shapira-Frommer, R.
Itzhaki, O.
Kubi, A.
Zikich, D.
Besser, Michal J.
Jacob, Schachter
Markel, Gal
Sivan, Sapoznik
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Malignant melanoma is a devastating disease whose incidences are continuously rising.
The recently approved antimelanoma therapies carry new hope for metastatic patients for the first time in decades.
However, the clinical management of melanoma is severely hampered by the absence of effective screening tools.
The expression of the CEACAM1 adhesion molecule on melanoma cells is a strong predictor of poor prognosis.
Interestingly, a melanoma-secreted form of CEACAM1 (sCEACAM1) has recently emerged as a potential tumor biomarker.
Here we add novel evidences supporting the prognostic role of serum CEACAM1 by using a mice xenograft model of human melanoma and showing a correlation between serum CEACAM1 and tumor burden.
Moreover, we demonstrate that serum CEACAM1 is elevated over time in progressive melanoma patients who fail to respond to immunotherapy as opposed to responders and stable disease patients, thus proving a correlation between sCEACAM1, response to treatment, and clinical deterioration.
American Psychological Association (APA)
Rona, Ortenberg& Sivan, Sapoznik& Zippel, D.& Shapira-Frommer, R.& Itzhaki, O.& Kubi, A.…[et al.]. 2015. Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068632
Modern Language Association (MLA)
Rona, Ortenberg…[et al.]. Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068632
American Medical Association (AMA)
Rona, Ortenberg& Sivan, Sapoznik& Zippel, D.& Shapira-Frommer, R.& Itzhaki, O.& Kubi, A.…[et al.]. Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068632