High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced ProctitisProctocolitis: Autoimmunity Involvement?
Joint Authors
Sekerkova, Alena
Fuchs, Martin
Cecrdlova, Eva
Svachova, Veronika
Kralova Lesna, Ivana
Striz, Ilja
Tlaskalova-Hogenova, Helena
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Food protein-induced proctitis/proctocolitis (FPIP) is the most common noninfectious colitis in children in the first year of life.
Along with the overall clinical symptoms, diarrhoea and rectal bleeding are the main manifestations of the disease.
There is no routine noninvasive test that would be specific for this type of colitis.
The aim of our study was to find a noninvasive laboratory test or tests that may be helpful in differential diagnosis of food protein-induced proctitis/proctocolitis.
Methods.
ANA, ANCA, ASCA, a-EMA, a-tTg, specific IgE, total IgE, IgG, IgA, IgM, and concentration of serum calprotectin were measured in a group of 25 patients with colitis and 18 children with other diagnoses.
Results.
Atypical-pANCA antibodies of IgG isotype were detected in the sera of 24 patients by the method of indirect immunofluorescence, and 5 patients showed also the positivity of IgA isotype.
In control samples these autoantibodies were not detected.
Other autoantibodies were not demonstrated in either patient or control group.
Conclusions.
Of the parameters tested in noninfectious colitis, atypical-pANCA on ethanol-fixed granulocytes appears to be a suitable serological marker of food protein-induced proctitis/proctocolitis and suggests a possible involvement of an autoimmune mechanisms in the pathogenesis of this disease.
American Psychological Association (APA)
Sekerkova, Alena& Fuchs, Martin& Cecrdlova, Eva& Svachova, Veronika& Kralova Lesna, Ivana& Striz, Ilja…[et al.]. 2015. High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced ProctitisProctocolitis: Autoimmunity Involvement?. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068634
Modern Language Association (MLA)
Sekerkova, Alena…[et al.]. High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced ProctitisProctocolitis: Autoimmunity Involvement?. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068634
American Medical Association (AMA)
Sekerkova, Alena& Fuchs, Martin& Cecrdlova, Eva& Svachova, Veronika& Kralova Lesna, Ivana& Striz, Ilja…[et al.]. High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced ProctitisProctocolitis: Autoimmunity Involvement?. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068634