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Clinical Options in Relapsed or Refractory Hodgkin Lymphoma: An Updated Review
Joint Authors
Fedele, Roberta
Martino, Massimo
Recchia, Anna Grazia
Irrera, Giuseppe
Morabito, Fortunato
Gentile, Massimo
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hodgkin lymphoma (HL) is a potentially curable lymphoma, and modern therapy is expected to successfully cure more than 80% of the patients.
Second-line salvage high-dose chemotherapy and autologous stem cell transplantation (auto-SCT) have an established role in the management of refractory and relapsed HL, leading to long-lasting responses in approximately 50% of relapsed patients and a minority of refractory patients.
Patients progressing after intensive treatments, such as auto-SCT, have a very poor outcome.
Allogeneic SCT represents the only strategy with a curative potential for these patients; however, its role is controversial.
Based on recent knowledge of HL pathology, biology, and immunology, antibody-drug conjugates targeting CD30, small molecule inhibitors of cell signaling, and antibodies that inhibit immune checkpoints are currently explored.
This review will discuss the clinical results regarding auto-SCT and allo-SCT as well as the current role of emerging new treatment strategies.
American Psychological Association (APA)
Fedele, Roberta& Martino, Massimo& Recchia, Anna Grazia& Irrera, Giuseppe& Gentile, Massimo& Morabito, Fortunato. 2015. Clinical Options in Relapsed or Refractory Hodgkin Lymphoma: An Updated Review. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068656
Modern Language Association (MLA)
Fedele, Roberta…[et al.]. Clinical Options in Relapsed or Refractory Hodgkin Lymphoma: An Updated Review. Journal of Immunology Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068656
American Medical Association (AMA)
Fedele, Roberta& Martino, Massimo& Recchia, Anna Grazia& Irrera, Giuseppe& Gentile, Massimo& Morabito, Fortunato. Clinical Options in Relapsed or Refractory Hodgkin Lymphoma: An Updated Review. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068656