Anti-PhosphatidylserineProthrombin Antibodies Are Associated with Adverse Pregnancy Outcomes
Joint Authors
Kveder, Tanja
Ambrožič, Aleš
Perdan Pirkmajer, Katja
Tomšič, Matija
Čučnik, Saša
Žigon, Polona
Sodin-Semrl, Snezna
Božič, Borut
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To determine the prevalence and clinical association of anti-phosphatidylserine/prothrombin antibodies (aPS/PT) in patients with a history of pregnancy complications relevant to antiphospholipid syndrome (APS).
Materials and Methods.
Two hundred and eleven patients with a history of (a) three or more consecutive miscarriages before 10th week of gestation (WG) (n=64), (b) death of a morphologically normal fetus beyond 10th WG (n=72), (c) premature birth of a morphologically normal neonate before 34th WG due to eclampsia, preeclamsia and placental insufficiency (n=33), and (d) less than three unexplained consecutive miscarriages before 10th WG (n=42).
Subjects sera were analyzed for lupus anticoagulant (LA), anti-cardiolipin (aCL), anti-β2-glycoprotein I (anti-β2GPI), and aPS/PT antibodies.
Results.
41/169 (24.3%) of patients were positive for at least one measured aPL.
The highest prevalence was found for aPS/PT and aCL (13.0% and 12.4%, resp.) followed by LA (7.7%) and anti-β2GPI (7.1%).
11/169 with APS-related obstetric manifestations had only aPS/PT.
17.8% of patients were positive for LA or aCL and/or anti-β2GPI; however when adding the aPS/PT results, an additional 7% of patients could be evaluated for APS.
Conclusion.
aPS/PT are associated with recurrent early or late abortions and with premature delivery irrespective of other aPL.
American Psychological Association (APA)
Žigon, Polona& Perdan Pirkmajer, Katja& Tomšič, Matija& Kveder, Tanja& Božič, Borut& Sodin-Semrl, Snezna…[et al.]. 2015. Anti-PhosphatidylserineProthrombin Antibodies Are Associated with Adverse Pregnancy Outcomes. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068657
Modern Language Association (MLA)
Žigon, Polona…[et al.]. Anti-PhosphatidylserineProthrombin Antibodies Are Associated with Adverse Pregnancy Outcomes. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068657
American Medical Association (AMA)
Žigon, Polona& Perdan Pirkmajer, Katja& Tomšič, Matija& Kveder, Tanja& Božič, Borut& Sodin-Semrl, Snezna…[et al.]. Anti-PhosphatidylserineProthrombin Antibodies Are Associated with Adverse Pregnancy Outcomes. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068657