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Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?
Joint Authors
Pyzik, Aleksandra
Grywalska, Ewelina
Matyjaszek-Matuszek, Beata
Roliński, Jacek
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This review of literature attempts to identify the factors that are involved in the pathogenesis of Hashimoto thyroiditis, an immune defect in an individual with genetic susceptibility accompanied with environmental factors.
The frequency of Hashimoto’s disease is a growing trend and among Caucasians it is estimated at approximately 5%.
The dysfunction of the gland may be clinically evident (0.1–2% of the population) or subclinical (10–15%).
The pathology is diagnosed five to ten times more often in women than men and its incidence increases with the age (the peak of the number of cases is between 45 and 65); however, it can also be diagnosed in children.
The pathogenesis of Hashimoto’s thyroiditis is still not fully comprehended.
In the etiology of Hashimoto thyroiditis excessively stimulated T CD4+ cells are known to play the most important role.
Recent research has demonstrated an increasing role of newly discovered cells such as Th17 (CD4+IL-17+) or T regulatory cells (CD4+CD25 + high FoxP3+) in the induction of autoimmune disorders.
The process of programmed cell death also plays an equally important role in the pathogenesis and the development of hypothyroidism.
American Psychological Association (APA)
Pyzik, Aleksandra& Grywalska, Ewelina& Matyjaszek-Matuszek, Beata& Roliński, Jacek. 2015. Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068658
Modern Language Association (MLA)
Pyzik, Aleksandra…[et al.]. Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068658
American Medical Association (AMA)
Pyzik, Aleksandra& Grywalska, Ewelina& Matyjaszek-Matuszek, Beata& Roliński, Jacek. Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068658