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Neutrophils in Cancer: Two Sides of the Same Coin
Joint Authors
Rosales, C.
Uribe-Querol, Eileen
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-24
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Neutrophils are the most abundant leukocytes in blood and are considered to be the first line of defense during inflammation and infections.
In addition, neutrophils are also found infiltrating many types of tumors.
Tumor-associated neutrophils (TANs) have relevant roles in malignant disease.
Indeed neutrophils may be potent antitumor effector cells.
However, increasing clinical evidence shows TANs correlate with poor prognosis.
The tumor microenvironment controls neutrophil recruitment and in turn TANs help tumor progression.
Hence, TANs can be beneficial or detrimental to the host.
It is the purpose of this review to highlight these two sides of the neutrophil coin in cancer and to describe recent studies that provide some light on the mechanisms for neutrophil recruitment to the tumor, for neutrophils supporting tumor progression, and for neutrophil activation to enhance their antitumor functions.
American Psychological Association (APA)
Uribe-Querol, Eileen& Rosales, C.. 2015. Neutrophils in Cancer: Two Sides of the Same Coin. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1068662
Modern Language Association (MLA)
Uribe-Querol, Eileen& Rosales, C.. Neutrophils in Cancer: Two Sides of the Same Coin. Journal of Immunology Research No. 2015 (2015), pp.1-21.
https://search.emarefa.net/detail/BIM-1068662
American Medical Association (AMA)
Uribe-Querol, Eileen& Rosales, C.. Neutrophils in Cancer: Two Sides of the Same Coin. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1068662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068662