Elevated Phospholipid Transfer Protein in Subjects with Multiple Sclerosis
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
An anomaly in the plasma proteins of patients with multiple sclerosis detectable on SDS-PAGE has been reported.
The molecular weight of the anomaly was the same as the phospholipid transfer protein.
A metabolic protein was involved in lipid homeostasis and remodeling of the high density lipoproteins.
We have identified the anomaly as the phospholipid transfer protein by western blot using antiphospholipid transfer antibodies.
Activity assays showed that the phospholipid transfer activity was elevated in fasted plasma samples from subjects with MS compared to controls.
Sequence analysis of the gene encoding the phospholipid transfer protein did not identify any mutations in the genetic structure, suggesting that the increase in activity was not due to structural changes in the protein, but may be due to one of the other proteins with which it forms active complexes.
Altered phospholipid transfer activity is important because it could be implicated in the decreased lipid uptake and abnormal myelin lipids observed in multiple sclerosis.
It has been shown that alteration in myelin lipid content is an epitope for autoimmunity.
Therefore, lipid changes due to a defect in phospholipid transfer and/or uptake could potentially influence the course of the disease.
Further research is needed to elucidate the role of the phospholipid transfer protein in subjects with multiple sclerosis.
American Psychological Association (APA)
Garvin, Roy A.. 2015. Elevated Phospholipid Transfer Protein in Subjects with Multiple Sclerosis. Journal of Lipids،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1068669
Modern Language Association (MLA)
Garvin, Roy A.. Elevated Phospholipid Transfer Protein in Subjects with Multiple Sclerosis. Journal of Lipids No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1068669
American Medical Association (AMA)
Garvin, Roy A.. Elevated Phospholipid Transfer Protein in Subjects with Multiple Sclerosis. Journal of Lipids. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1068669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068669