Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E24 Carriers: The Effect of an Apparent Duality
Joint Authors
Gaudet, Daniel
Villeneuve, Sylvia
Brisson, Diane
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Apolipoprotein (Apo) E plays a key role in the handling of lipoprotein particles with ApoE2 and ApoE4 frequently having opposite effects compared to ApoE3.
Some individuals simultaneously carry both E2 and E4 alleles.
The impact of the ApoE2/4 genotype on lipid concentrations and its consequences on health remain poorly documented.
Objective.
This study compared the lipid profile between ApoE2/4 carriers and other ApoE genotypes in relation to the waist circumference.
Methods.
Cholesterol, triglyceride (TG), and ApoB concentrations were measured among 2,680 Caucasians.
Multivariate logistic regression models were used to estimate the contribution of ApoE2/4 to various dyslipidemic profiles associated with abdominal obesity.
Results.
In presence of abdominal obesity, the lipid profile was as deteriorated in ApoE2/4 carriers as in carriers of other ApoE genotypes.
There was a more pronounced effect on TG-rich lipoproteins, particularly in ApoE2/2 (a feature of type III dysbetalipoproteinemia), and non-high-density lipoprotein (HDL) cholesterol in ApoE4/4.
Compared to ApoE2/2, ApoE2/4 carriers presented lower very-low-density lipoprotein (VLDL) cholesterol concentrations and VLDL-cholesterol/TG ratios, with or without obesity, and higher low-density lipoprotein (LDL) cholesterol concentrations.
Conclusion.
In presence of abdominal obesity, the influence of the ApoE2 allele could be less pronounced than that of ApoE4 among ApoE2/4 individuals.
American Psychological Association (APA)
Villeneuve, Sylvia& Brisson, Diane& Gaudet, Daniel. 2015. Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E24 Carriers: The Effect of an Apparent Duality. Journal of Lipids،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068671
Modern Language Association (MLA)
Villeneuve, Sylvia…[et al.]. Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E24 Carriers: The Effect of an Apparent Duality. Journal of Lipids No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068671
American Medical Association (AMA)
Villeneuve, Sylvia& Brisson, Diane& Gaudet, Daniel. Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E24 Carriers: The Effect of an Apparent Duality. Journal of Lipids. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068671