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miRNA Influences in NRF2 Pathway Interactions within Cancer Models
Joint Authors
Ayers, Duncan
Baron, Byron
Hunter, Therese
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The NRF2 transcription factor (nuclear factor-erythroid 2 p45-related factor 2) has been identified as a key molecular player in orchestrating adaptive cellular interactions following a wide spectrum of cellular stress conditions that could be either extracellular or intracellular.
Dysregulation of the NRF2 system is implicated in various disease states, including inflammatory conditions.
The NRF2 transcription factor is also known to permit cross talk with several other essential cellular signaling pathways.
Recent literature has also elucidated the potential influences of miRNA activity over modulations of the NRF2 signalling network.
Consequently, further delving into the knowledge regarding the extent of miRNA-induced epigenetic gene regulatory control on key elements of the NRF2 signalling pathway and its cross talk, particularly within the context of cancer models, can prove to be of high clinical importance.
This is so since such miRNAs, once identified and validated, can be potentially exploited as novel drug targets for emerging translational medicine-based therapies.
American Psychological Association (APA)
Ayers, Duncan& Baron, Byron& Hunter, Therese. 2015. miRNA Influences in NRF2 Pathway Interactions within Cancer Models. Journal of Nucleic Acids،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068713
Modern Language Association (MLA)
Ayers, Duncan…[et al.]. miRNA Influences in NRF2 Pathway Interactions within Cancer Models. Journal of Nucleic Acids No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068713
American Medical Association (AMA)
Ayers, Duncan& Baron, Byron& Hunter, Therese. miRNA Influences in NRF2 Pathway Interactions within Cancer Models. Journal of Nucleic Acids. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068713