Nanomaterials-Based Approaches for the Modulation of Sodium Bicarbonate Cotransporters
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
HC O 3 - and fluid secretion are major functions of all epithelia, and alterations in HCO3- secretion by sodium bicarbonate cotransporters are associated with many epithelial diseases, such as renal, ocular, and dental abnormalities.
Electrolyte and fluid exits are synergistically mediated by the intracellular second messengers, cAMP and Ca2+, and this raises the possibility that ion transporters are involved in simple secretion and more complicated forms of regulation.
Evidence indicates that HCO3- transport is regulated by the assemblage of Na+-HCO3- cotransporters (NBCs) into complexes by multiple regulatory factors.
Recently the specific regulatory functions of factors that interact with NBCe1, especially NBCe1-B, have been elucidated.
In this review, I focus on the structural characteristics of electrogenic NBCe1, pathophysiology of NBCe1, and molecular mechanisms responsible for transporter regulation.
Moreover I propose the possibility to apply nanomaterials combined with regulatory factors for modulating the activity of NBC transporters as a potential development of therapeutic drug.
American Psychological Association (APA)
Hong, Jeong Hee. 2015. Nanomaterials-Based Approaches for the Modulation of Sodium Bicarbonate Cotransporters. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068732
Modern Language Association (MLA)
Hong, Jeong Hee. Nanomaterials-Based Approaches for the Modulation of Sodium Bicarbonate Cotransporters. Journal of Nanomaterials No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068732
American Medical Association (AMA)
Hong, Jeong Hee. Nanomaterials-Based Approaches for the Modulation of Sodium Bicarbonate Cotransporters. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068732