![](/images/graphics-bg.png)
Comparison of the Effect of Sol-Gel and Coprecipitation Routes on the Properties and Behavior of Nanocomposite Chitosan-Bioactive Glass Membranes for Bone Tissue Engineering
Joint Authors
Lemos, Elke M. F.
Carvalho, Sandhra M.
Patrício, Patrícia S. O.
Donnici, Claudio L.
Pereira, Marivalda M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Recent studies in tissue engineering have highlighted the importance of the development of composite materials based on biodegradable polymers containing bioactive glasses, in particular, composites for high load support and excellent cell viability for potential application in bone regeneration.
In this work, hybrid composite films were obtained by combining chitosan with bioactive glass in solution form and in nanoparticle dispersion form obtained by the two different synthesis routes: the sol-gel method and coprecipitation.
The bioactive glass served both as a mechanical reinforcing agent and as a triggering agent with high bioactivity.
The results of in vitro assays with simulated body fluid demonstrated the formation of a significant layer of fibrils on the surface of the film, with a typical morphology of carbonated hydroxyapatite, reflecting induction of a favorable bioactivity.
Maximum tensile stress increased from 42 to 80 MPa to the sample with 5% wt bioactive glass.
In addition, samples containing 5% and 10% wt bioactive glass showed a significant increase in cell viability, 18 and 30% increase compared to the control group.
The samples showed significant response, indicating that they could be a potential material for use in bone regeneration through tissue engineering.
American Psychological Association (APA)
Lemos, Elke M. F.& Carvalho, Sandhra M.& Patrício, Patrícia S. O.& Donnici, Claudio L.& Pereira, Marivalda M.. 2015. Comparison of the Effect of Sol-Gel and Coprecipitation Routes on the Properties and Behavior of Nanocomposite Chitosan-Bioactive Glass Membranes for Bone Tissue Engineering. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068772
Modern Language Association (MLA)
Lemos, Elke M. F.…[et al.]. Comparison of the Effect of Sol-Gel and Coprecipitation Routes on the Properties and Behavior of Nanocomposite Chitosan-Bioactive Glass Membranes for Bone Tissue Engineering. Journal of Nanomaterials No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068772
American Medical Association (AMA)
Lemos, Elke M. F.& Carvalho, Sandhra M.& Patrício, Patrícia S. O.& Donnici, Claudio L.& Pereira, Marivalda M.. Comparison of the Effect of Sol-Gel and Coprecipitation Routes on the Properties and Behavior of Nanocomposite Chitosan-Bioactive Glass Membranes for Bone Tissue Engineering. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068772