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Ball Milling to Build the Hybrid Mesocrystals of Ibuprofen and Aragonite
Joint Authors
Kim, Il Won
Cho, Kyoung A
Choi, Insil
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mesocrystal formation is one of the new paradigms of the nonclassical crystallization, where the assembly of crystal domains is observed.
Also, it has been recently employed in studies on drug formulation to utilize controlled dissolution of the drug domains.
In this report, ibuprofen was attempted to form hybrid mesocrystals with calcium carbonate crystals.
Two polymorphs of calcium carbonate (aragonite and calcite) were used during the solid-state process of ball milling.
Structural analyses confirmed the mesocrystal formation of ibuprofen with aragonite but not with calcite.
The origin of the observed behavior was found from the higher affinity of ibuprofen to aragonite, especially its (0 1 0) surface, compared to calcite.
The hybrid mesocrystals of ibuprofen and aragonite showed the environment-responsive release behavior, where the stability of aragonite was the controlling factor for the release kinetics of ibuprofen.
American Psychological Association (APA)
Cho, Kyoung A& Choi, Insil& Kim, Il Won. 2015. Ball Milling to Build the Hybrid Mesocrystals of Ibuprofen and Aragonite. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068781
Modern Language Association (MLA)
Cho, Kyoung A…[et al.]. Ball Milling to Build the Hybrid Mesocrystals of Ibuprofen and Aragonite. Journal of Nanomaterials No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068781
American Medical Association (AMA)
Cho, Kyoung A& Choi, Insil& Kim, Il Won. Ball Milling to Build the Hybrid Mesocrystals of Ibuprofen and Aragonite. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068781