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Synthesis and Antibacterial Activity of Antibiotic-Functionalized Graphite Nanofibers
Joint Authors
Rotella, Madeline
Briegel, Alicia
Hull, John
Lagalante, Anthony
Giuliano, Robert
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Surface functionalization of nanomaterials is an area of current investigation that supports the development of new biomaterials for applications in biology and medicine.
Herein we describe the synthesis, characterization, and antibacterial properties of the first examples of antibiotic-labeled graphitic carbon nanofibers (GCNFs) covalently functionalized with aminoglycoside and quinolone antibiotics.
Ruthenium tetroxide oxidation of herringbone GCNFs gave higher amounts of surface carboxyl groups than previous methods.
These carboxyl groups served as sites of attachment for antibiotics by acyl substitution.
Bioassay of these novel, functionalized GCNFs using serial dilution and optical density methods demonstrated that antibiotic-labeled GCNFs possess significant antibacterial activity against Pseudomonas aeruginosa.
The activity we observe for aminoglycoside-functionalized GCNFs suggests a membranolytic mechanism of action.
American Psychological Association (APA)
Rotella, Madeline& Briegel, Alicia& Hull, John& Lagalante, Anthony& Giuliano, Robert. 2015. Synthesis and Antibacterial Activity of Antibiotic-Functionalized Graphite Nanofibers. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068817
Modern Language Association (MLA)
Rotella, Madeline…[et al.]. Synthesis and Antibacterial Activity of Antibiotic-Functionalized Graphite Nanofibers. Journal of Nanomaterials No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068817
American Medical Association (AMA)
Rotella, Madeline& Briegel, Alicia& Hull, John& Lagalante, Anthony& Giuliano, Robert. Synthesis and Antibacterial Activity of Antibiotic-Functionalized Graphite Nanofibers. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068817