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Nanosuspension Technologies for Delivery of Poorly Soluble Drugs
Joint Authors
Vasilev, Krasimir
Yadollahi, Roya
Simovic, Spomenka
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Poor aqueous solubility of some drug molecules is a major problem in drug formulation.
Drug nanosuspensions emerged as one solution to delivering such hydrophobic drugs.
Scaling down to nanoparticles enhances drug aqueous solubility and bioavailability by increasing drug surface area that comes into contact with biological media.
Nanosuspensions that have attracted particular attention are those sterically stabilised by steric polymers such as polyethylene glycol (PEG) with a typical size range of 10–100 nm.
These nanoparticles are capable of accumulating in targeted areas such as cancer tissues and infarct zones with minimal damage to healthy tissues.
Nanosuspensions are often prepared by commercially available methods such as high pressure homogenization, media milling, emulsification, and melt emulsification.
Solidification and surface modification methods are post-processing techniques used to add particular properties for advanced therapies.
In this review, we firstly describe preparation methods for nanosuspensions.
Secondly, we highlight typical characterization techniques.
Finally, we describe several practical application of applications for drug delivery design and different administration routes such as parenteral, pulmonary, oral, and ocular.
American Psychological Association (APA)
Yadollahi, Roya& Vasilev, Krasimir& Simovic, Spomenka. 2015. Nanosuspension Technologies for Delivery of Poorly Soluble Drugs. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068828
Modern Language Association (MLA)
Yadollahi, Roya…[et al.]. Nanosuspension Technologies for Delivery of Poorly Soluble Drugs. Journal of Nanomaterials No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1068828
American Medical Association (AMA)
Yadollahi, Roya& Vasilev, Krasimir& Simovic, Spomenka. Nanosuspension Technologies for Delivery of Poorly Soluble Drugs. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068828