5-Fluorouracil-Loaded Transfersome as Theranostics in Dermal Tumor of Hypertrophic Scar Tissue
Joint Authors
Zhang, Z.
Wang, X.
Chen, X.
Wo, Y.
Zhang, Y.
Biskup, Ewelina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To investigate the ability of transfersomal gel carrying the antiscarring agent (5-FU) to permeate hypertrophic scars in vivo and in vitro, scar permeation studies were performed after the agent was labeled with the fluorescent agent, rhodamine 6GO.
Laser confocal microscope was employed to dynamically observe the effects of transfersomal gel carrying 5-FU at different time points.
High-performance liquid chromatography (HPLC) was used to analyze the contents of the agent in the scar tissues at different hours after administration.
Scar elevation index (SEI) was used to evaluate the changes of the ear scar models in rabbits.
Compared with the PBS gel of 5-FU, the transfersomal gel displayed greater permeation rate and depth, as well as a higher content retention of the agent in scar tissues.
Local administrations of the agent for some certain periods effectively inhibited the hyperplasia of ear scars in rabbits.
Transfersomes can be chosen as a potential transdermal drug delivery system.
American Psychological Association (APA)
Zhang, Z.& Wang, X.& Chen, X.& Wo, Y.& Zhang, Y.& Biskup, Ewelina. 2015. 5-Fluorouracil-Loaded Transfersome as Theranostics in Dermal Tumor of Hypertrophic Scar Tissue. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068858
Modern Language Association (MLA)
Zhang, Z.…[et al.]. 5-Fluorouracil-Loaded Transfersome as Theranostics in Dermal Tumor of Hypertrophic Scar Tissue. Journal of Nanomaterials No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068858
American Medical Association (AMA)
Zhang, Z.& Wang, X.& Chen, X.& Wo, Y.& Zhang, Y.& Biskup, Ewelina. 5-Fluorouracil-Loaded Transfersome as Theranostics in Dermal Tumor of Hypertrophic Scar Tissue. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068858