In Vivo Osteogenesis of Vancomycin Loaded NanohydroxyapatiteCollagenCalcium Sulfate Composite for Treating Infectious Bone Defect Induced by Chronic Osteomyelitis
Joint Authors
Wang, Xiu-Mei
Lian, Xiaojie
Mao, Kezheng
Liu, Xi
Cui, Fuzhai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A novel antibacterial bone graft substitute was developed to repair bone defects and to inhibit related infections simultaneously.
This bone composite was prepared by introducing vancomycin (VCM) to nanohydroxyapatite/collagen/calcium sulphate hemihydrate (nHAC/CSH).
XRD, SEM, and CCK-8 tests were used to characterize the structure and morphology and to investigate the adhesion and proliferation of murine osteoblastic MC3T3-E1 cell on VCM/nHAC/CSH composite.
The effectiveness in restoring infectious bone defects was evaluated in vivo using a rabbit model of chronic osteomyelitis.
Our in vivo results implied that the VCM/nHAC/CSH composite performed well both in antibacterial ability and in bone regeneration.
This novel bone graft substitute should be very promising for the treatment of bone defect-related infection in orthopedic surgeries.
American Psychological Association (APA)
Lian, Xiaojie& Mao, Kezheng& Liu, Xi& Wang, Xiu-Mei& Cui, Fuzhai. 2015. In Vivo Osteogenesis of Vancomycin Loaded NanohydroxyapatiteCollagenCalcium Sulfate Composite for Treating Infectious Bone Defect Induced by Chronic Osteomyelitis. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068865
Modern Language Association (MLA)
Lian, Xiaojie…[et al.]. In Vivo Osteogenesis of Vancomycin Loaded NanohydroxyapatiteCollagenCalcium Sulfate Composite for Treating Infectious Bone Defect Induced by Chronic Osteomyelitis. Journal of Nanomaterials No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068865
American Medical Association (AMA)
Lian, Xiaojie& Mao, Kezheng& Liu, Xi& Wang, Xiu-Mei& Cui, Fuzhai. In Vivo Osteogenesis of Vancomycin Loaded NanohydroxyapatiteCollagenCalcium Sulfate Composite for Treating Infectious Bone Defect Induced by Chronic Osteomyelitis. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068865