In Vivo Osteogenesis of Vancomycin Loaded NanohydroxyapatiteCollagenCalcium Sulfate Composite for Treating Infectious Bone Defect Induced by Chronic Osteomyelitis

Abstract EN

A novel antibacterial bone graft substitute was developed to repair bone defects and to inhibit related infections simultaneously.

This bone composite was prepared by introducing vancomycin (VCM) to nanohydroxyapatite/collagen/calcium sulphate hemihydrate (nHAC/CSH).

XRD, SEM, and CCK-8 tests were used to characterize the structure and morphology and to investigate the adhesion and proliferation of murine osteoblastic MC3T3-E1 cell on VCM/nHAC/CSH composite.

The effectiveness in restoring infectious bone defects was evaluated in vivo using a rabbit model of chronic osteomyelitis.

Our in vivo results implied that the VCM/nHAC/CSH composite performed well both in antibacterial ability and in bone regeneration.

This novel bone graft substitute should be very promising for the treatment of bone defect-related infection in orthopedic surgeries.