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Effect of Lipophilic Bismuth Nanoparticles on Erythrocytes
Joint Authors
Hernandez-Delgadillo, Rene
Badireddy, Appala Raju
Zaragoza-Magaña, Valentin
Sánchez-Nájera, Rosa Isela
Chellam, Shankararaman
Cabral-Romero, Claudio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Lipophilic bismuth dimercaptopropanol nanoparticles (BisBAL NPs) have a very important antimicrobial activity; however their effect on human cells or tissues has not been completely studied.
Undesirable effects of bismuth include anemia which could result from suicidal erythrocyte death or eryptosis.
The objective of this research was to determine the effect of bismuth dimercaptopropanol nanoparticles on blood cells.
The nanoparticles are composed of 53 nm crystallites on average and have a spherical structure, agglomerating into clusters of small nanoparticles.
Based on cell viability assays and optical microscopy, cytotoxicity on erythrocytes was observed after growing with 500 and 1000 µM of BisBAL NPs for 24 h.
AM Calcein was retained inside erythrocytes when they were exposed to 100 µM (or lower concentrations) of BisBAL NPs for 24 h, suggesting the absence of damage in plasmatic membrane.
Genotoxic assays revealed no damage to genomic DNA of blood cells after 24 h of exposition to BisBAL NPs.
Finally, 100–1000 µM of bismuth nanoparticles promotes apoptosis between blood cells after 24 h of incubation.
Hence BisBAL NPs at concentrations lower than 100 µM do not cause damage on blood cells; they could potentially be used by humans without affecting erythrocytes and leukocytes.
American Psychological Association (APA)
Hernandez-Delgadillo, Rene& Badireddy, Appala Raju& Zaragoza-Magaña, Valentin& Sánchez-Nájera, Rosa Isela& Chellam, Shankararaman& Cabral-Romero, Claudio. 2015. Effect of Lipophilic Bismuth Nanoparticles on Erythrocytes. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068867
Modern Language Association (MLA)
Hernandez-Delgadillo, Rene…[et al.]. Effect of Lipophilic Bismuth Nanoparticles on Erythrocytes. Journal of Nanomaterials No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068867
American Medical Association (AMA)
Hernandez-Delgadillo, Rene& Badireddy, Appala Raju& Zaragoza-Magaña, Valentin& Sánchez-Nájera, Rosa Isela& Chellam, Shankararaman& Cabral-Romero, Claudio. Effect of Lipophilic Bismuth Nanoparticles on Erythrocytes. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068867