Development of a Composite Electrospun Polyethylene Terephthalate-Polyglycolic Acid Material: Potential Use as a Drug-Eluting Vascular Graft
Joint Authors
Nabzdyk, Christoph S.
Chun, Maggie
Pathan, Saif G.
Nelson, David W.
You, Jin-Oh
Phaneuf, Matthew D.
LoGerfo, Frank W.
Pradhan-Nabzdyk, Leena
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Intimal hyperplasia (IH), an excessive wound healing response of an injured vessel wall after bypass grafting, typically leads to prosthetic bypass graft failure.
In an approach to ameliorate IH, nondegradable poly(ethylene terephthalate) or PET, which has been used in prosthetic vascular grafts for over 60 years, and biodegradable poly(glycolic acid) or PGA were electrospun using different techniques to generate a material that may serve as permanent scaffold and as a drug/biologic delivery device.
PET and PGA polymers were electrospun from either a single-blended solution (ePET/ePGA-s) or two separate polymer solutions (ePET/ePGA-d).
ePET/ePGA-d material revealed two distinct fibers and was significantly stronger than the single fiber ePET/ePGA-s material.
After 21 days of incubation in PBS, ePET-PGA-s showed fiber strand breaks likely due to the degradation of the PGA within the ePET-ePGA-s fiber, while the ePET/ePGA-d material showed intact ePET fibers even after ePGA fiber degradation.
The ePET/ePGA- material was able to release red fluorescent dye for at least 14 days.
Attachment of human aortic smooth muscle cells (AoSMCs) was similar to both materials.
ePET/ePGA-d materials maybe a step towards bypass graft materials that can be custom-designed to promote cellular attachment while serving as a drug delivery platform for IH prevention.
American Psychological Association (APA)
Nabzdyk, Christoph S.& Chun, Maggie& Pathan, Saif G.& Nelson, David W.& You, Jin-Oh& Phaneuf, Matthew D.…[et al.]. 2015. Development of a Composite Electrospun Polyethylene Terephthalate-Polyglycolic Acid Material: Potential Use as a Drug-Eluting Vascular Graft. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068927
Modern Language Association (MLA)
Nabzdyk, Christoph S.…[et al.]. Development of a Composite Electrospun Polyethylene Terephthalate-Polyglycolic Acid Material: Potential Use as a Drug-Eluting Vascular Graft. Journal of Nanomaterials No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068927
American Medical Association (AMA)
Nabzdyk, Christoph S.& Chun, Maggie& Pathan, Saif G.& Nelson, David W.& You, Jin-Oh& Phaneuf, Matthew D.…[et al.]. Development of a Composite Electrospun Polyethylene Terephthalate-Polyglycolic Acid Material: Potential Use as a Drug-Eluting Vascular Graft. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068927