Porous PCLChitosan and nHAPCLChitosan Scaffolds for Tissue Engineering Applications: Fabrication and Evaluation
Joint Authors
Sultana, Naznin
Hamdan, Salehhuddin
Mad Jin, Rashid
Baba, Sayang
Ismail, Ahmad Fauzi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Two semicrystalline polymers were blended to fabricate porous scaffolds for tissue engineering applications.
Scaffolds containing polycaprolactone (PCL)/chitosan and nanohydroxyapatite (nHA) incorporated nHA/PCL/chitosan were produced using the freeze-drying technique.
A model drug, tetracycline hydrochloride (tetracycline HCL), was incorporated into the scaffolds.
The scaffolds were characterized using a scanning electron microscope (SEM), EDX, and water contact angle.
The antibacterial properties of the nHA/PCL/chitosan/tetracycline HCL scaffold were tested and the scaffolds showed positive results on gram-positive and gram-negative bacteria.
The cell biocompatibility using human skin fibroblast cells (HSF 1184) was examined.
The scaffold materials were found to be nontoxic to human skin fibroblast cells (HSF 1184) and showed positive proliferation activities.
The nHA/PCL/chitosan/tetracycline HCL scaffold has potential for controlling implant-associated bacterial infections during operative procedures and can potentially be used as a scaffold for tissue engineering applications.
American Psychological Association (APA)
Mad Jin, Rashid& Sultana, Naznin& Baba, Sayang& Hamdan, Salehhuddin& Ismail, Ahmad Fauzi. 2015. Porous PCLChitosan and nHAPCLChitosan Scaffolds for Tissue Engineering Applications: Fabrication and Evaluation. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068937
Modern Language Association (MLA)
Mad Jin, Rashid…[et al.]. Porous PCLChitosan and nHAPCLChitosan Scaffolds for Tissue Engineering Applications: Fabrication and Evaluation. Journal of Nanomaterials No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068937
American Medical Association (AMA)
Mad Jin, Rashid& Sultana, Naznin& Baba, Sayang& Hamdan, Salehhuddin& Ismail, Ahmad Fauzi. Porous PCLChitosan and nHAPCLChitosan Scaffolds for Tissue Engineering Applications: Fabrication and Evaluation. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068937