Porous PCLChitosan and nHAPCLChitosan Scaffolds for Tissue Engineering Applications: Fabrication and Evaluation

Joint Authors

Sultana, Naznin
Hamdan, Salehhuddin
Mad Jin, Rashid
Baba, Sayang
Ismail, Ahmad Fauzi

Source

Journal of Nanomaterials

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-05-18

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Chemistry
Civil Engineering

Abstract EN

Two semicrystalline polymers were blended to fabricate porous scaffolds for tissue engineering applications.

Scaffolds containing polycaprolactone (PCL)/chitosan and nanohydroxyapatite (nHA) incorporated nHA/PCL/chitosan were produced using the freeze-drying technique.

A model drug, tetracycline hydrochloride (tetracycline HCL), was incorporated into the scaffolds.

The scaffolds were characterized using a scanning electron microscope (SEM), EDX, and water contact angle.

The antibacterial properties of the nHA/PCL/chitosan/tetracycline HCL scaffold were tested and the scaffolds showed positive results on gram-positive and gram-negative bacteria.

The cell biocompatibility using human skin fibroblast cells (HSF 1184) was examined.

The scaffold materials were found to be nontoxic to human skin fibroblast cells (HSF 1184) and showed positive proliferation activities.

The nHA/PCL/chitosan/tetracycline HCL scaffold has potential for controlling implant-associated bacterial infections during operative procedures and can potentially be used as a scaffold for tissue engineering applications.

American Psychological Association (APA)

Mad Jin, Rashid& Sultana, Naznin& Baba, Sayang& Hamdan, Salehhuddin& Ismail, Ahmad Fauzi. 2015. Porous PCLChitosan and nHAPCLChitosan Scaffolds for Tissue Engineering Applications: Fabrication and Evaluation. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068937

Modern Language Association (MLA)

Mad Jin, Rashid…[et al.]. Porous PCLChitosan and nHAPCLChitosan Scaffolds for Tissue Engineering Applications: Fabrication and Evaluation. Journal of Nanomaterials No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068937

American Medical Association (AMA)

Mad Jin, Rashid& Sultana, Naznin& Baba, Sayang& Hamdan, Salehhuddin& Ismail, Ahmad Fauzi. Porous PCLChitosan and nHAPCLChitosan Scaffolds for Tissue Engineering Applications: Fabrication and Evaluation. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068937

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1068937