VP6-SUMO Self-Assembly as Nanocarriers for Gastrointestinal Delivery
Joint Authors
Bugli, Francesca
Arcovito, A.
Papi, Massimiliano
Maulucci, Giuseppe
Palmieri, Valentina
De Spirito, Marco
Ciasca, G.
Galgano, S.
Sanguinetti, Maurizio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
High proteolytic degradation and poor absorption through epithelial barriers are major challenges to successful oral delivery of therapeutics.
Nanoparticle platforms can enhance drug stability and extend the residence time in gastrointestinal (GI) tract.
However, drug delivery systems are often inactivated in acidic environment of stomach or suffer poor absorption from intestinal cells due to the mucus layer.
To overcome these issues we developed a drug delivery system constituted by a protein construct made by a Rotavirus capsid protein (VP6) and the small ubiquitin-like modifier SUMO.
This chimeric construct allows specificity towards intestinal cells, the Rotavirus natural target, combined by an enhanced stability given by the eukaryotic protein transporter SUMO.
Furthermore SUMO can act as a molecular switch that facilitates import/export of its ligand to the nucleus, the hypersensitive subcellular site target of many cell killing therapies.
In this paper we show that SUMO-VP6 constructs self-assembly into stable nanocarriers.
SUMO-VP6 nanocarriers display ideal features for drug delivery: a small size and high monodispersity, a high stability in different pH conditions and a high uptake in the nuclear and cytoplasmic compartment of intestinal cells.
These features make SUMO-VP6 nanocarriers a promising novel system for oral delivery of poorly soluble drugs.
American Psychological Association (APA)
Palmieri, Valentina& Bugli, Francesca& Papi, Massimiliano& Ciasca, G.& Maulucci, Giuseppe& Galgano, S.…[et al.]. 2015. VP6-SUMO Self-Assembly as Nanocarriers for Gastrointestinal Delivery. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068962
Modern Language Association (MLA)
Palmieri, Valentina…[et al.]. VP6-SUMO Self-Assembly as Nanocarriers for Gastrointestinal Delivery. Journal of Nanomaterials No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068962
American Medical Association (AMA)
Palmieri, Valentina& Bugli, Francesca& Papi, Massimiliano& Ciasca, G.& Maulucci, Giuseppe& Galgano, S.…[et al.]. VP6-SUMO Self-Assembly as Nanocarriers for Gastrointestinal Delivery. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068962