![](/images/graphics-bg.png)
Preparation of Homogeneous Nanostructures in 5 Minutes for Cancer Cells Capture
Joint Authors
Wang, Lixue
Zhu, Chuandong
Zheng, Qin
He, Xia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Grafting aptamers on nanostructured substrates has shown ultrasensitivity in isolation of circulating tumor cells (CTCs).
Here, we report that over 80 cm2 of homogenous nanostructured surface on glass substrates can be prepared in 5 min after one-step dry etching.
The surface area was doubled; the average diameter of nanostructures is approximately 374 nm, which is more close to the nanostructures of natural extracellular matrix.
Antiepithelial cell adhesion molecule aptamers grafted nanostructured glass substrates captured over 76% of PC3 cells compared to 30% of planar substrates.
Bispecific aptamers cofunctionalized nanostructured substrates, however, fail to capture cancer cells probably due to the formation of heterodimers.
This limitation reveals that multispecific aptamers, when applied to cell isolation, must be analyzed to exclude any potential formation of heterodimers due to complementary sequence matching.
American Psychological Association (APA)
Wang, Lixue& Zhu, Chuandong& Zheng, Qin& He, Xia. 2015. Preparation of Homogeneous Nanostructures in 5 Minutes for Cancer Cells Capture. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068977
Modern Language Association (MLA)
Wang, Lixue…[et al.]. Preparation of Homogeneous Nanostructures in 5 Minutes for Cancer Cells Capture. Journal of Nanomaterials No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068977
American Medical Association (AMA)
Wang, Lixue& Zhu, Chuandong& Zheng, Qin& He, Xia. Preparation of Homogeneous Nanostructures in 5 Minutes for Cancer Cells Capture. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068977