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Development of Drug Loaded Nanoparticles Binding to Hydroxyapatite Based on a Bisphosphonate Modified Nonionic Surfactant
Joint Authors
Zhang, Jiabin
Liu, Xinrong
Deng, Tongming
Yao, Peng
Song, Heliang
Zhou, Shaobing
Yan, Weili
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study aimed at development of drug loaded nanoparticles which could bind to hydroxyapatite (HA) to construct drug or growth factor releasing bone graft substitutes.
To this end, the terminal hydroxyl group of a nonionic surfactant Brij 78 (polyoxyethylene (20) stearyl ether) was first modified with pamidronate (Pa).
Using Pa-Brij 78 as both a surfactant and an affinity ligand to HA, three different Pa surface functionalized nanoparticles were prepared, named as solid lipid nanoparticles (Pa-SNPs), nanoemulsions (Pa-NEMs), and PLGA nanoparticles (Pa-PNPs).
A model drug curcumin was successfully encapsulated in the three nanoparticles.
The sizes of Pa-NEM and Pa-PNP were around 150 nm and the size of Pa-SNP was around 90 nm with polydispersity indexes (PDIs) less than 0.20.
Drug encapsulation efficiencies of the three nanoparticles were all greater than 85%.
Furthermore, the order of binding affinity of the nanoparticles to HA was Pa-PNP > Pa-NEM = Pa-SNP .
After lyophilization, the sizes of the three nanoparticles were increased about 0.5–2.0-fold but their binding affinities to HA were almost the same as the fresh prepared nanoparticles.
In conclusion, a Pa-modified Brij 78 was synthesized and used for fabrication of a series of drug loaded nanoparticles to construct drug-eluting HA-based bone graft substitutes.
American Psychological Association (APA)
Zhang, Jiabin& Liu, Xinrong& Deng, Tongming& Yao, Peng& Song, Heliang& Zhou, Shaobing…[et al.]. 2015. Development of Drug Loaded Nanoparticles Binding to Hydroxyapatite Based on a Bisphosphonate Modified Nonionic Surfactant. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068980
Modern Language Association (MLA)
Zhang, Jiabin…[et al.]. Development of Drug Loaded Nanoparticles Binding to Hydroxyapatite Based on a Bisphosphonate Modified Nonionic Surfactant. Journal of Nanomaterials No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068980
American Medical Association (AMA)
Zhang, Jiabin& Liu, Xinrong& Deng, Tongming& Yao, Peng& Song, Heliang& Zhou, Shaobing…[et al.]. Development of Drug Loaded Nanoparticles Binding to Hydroxyapatite Based on a Bisphosphonate Modified Nonionic Surfactant. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068980