PAMAM Dendrimers as Potential Carriers of Gadolinium Complexes of Iminodiacetic Acid Derivatives for Magnetic Resonance Imaging
Joint Authors
Sikora, Joanna
Mikiciuk-Olasik, Elżbieta
Markowicz-Piasecka, Magdalena
Szymański, Paweł
Kozak, Oliwia
Studniarek, Michał
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This is the first study describing the utilization of PAMAM dendrimers as delivery vehicles of novel magnetic resonance imaging (MRI) contrast agents.
The purpose of this paper was to establish the potential of G4 PAMAM dendrimers as carriers of gadolinium complexes of iminodiacetic acid derivatives and determine imaging properties of synthesized compounds in in vivo studies.
Furthermore, we examined the influence of four synthesized complexes on the process of clot formation, stabilization, and lysis and on amidolytic activity of thrombin.
Biodistribution studies have shown that the compounds composed of PAMAM G4 dendrimers and gadolinium complexes of iminodiacetic acid derivatives increase signal intensity preferably in liver in range of 59–116% in MRI studies which corresponds with the greatest accumulation of gadolinium after administration of the compounds.
Synthesized compounds affect kinetic parameters of the proces of clot formation, its stabilization, and lysis.
However, only one synthesized compound at concentration 10-fold higher than potential plasma concentrations contributed to the increase of general parameters such as the overall potential of clot formation and lysis (↑CLAUC) and total time of the process (↑T).
Results of described studies provide additional insight into delivery properties of PAMAM dendrimers but simultaneously underscore the necessity for further research.
American Psychological Association (APA)
Markowicz-Piasecka, Magdalena& Sikora, Joanna& Szymański, Paweł& Kozak, Oliwia& Studniarek, Michał& Mikiciuk-Olasik, Elżbieta. 2015. PAMAM Dendrimers as Potential Carriers of Gadolinium Complexes of Iminodiacetic Acid Derivatives for Magnetic Resonance Imaging. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068982
Modern Language Association (MLA)
Markowicz-Piasecka, Magdalena…[et al.]. PAMAM Dendrimers as Potential Carriers of Gadolinium Complexes of Iminodiacetic Acid Derivatives for Magnetic Resonance Imaging. Journal of Nanomaterials No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068982
American Medical Association (AMA)
Markowicz-Piasecka, Magdalena& Sikora, Joanna& Szymański, Paweł& Kozak, Oliwia& Studniarek, Michał& Mikiciuk-Olasik, Elżbieta. PAMAM Dendrimers as Potential Carriers of Gadolinium Complexes of Iminodiacetic Acid Derivatives for Magnetic Resonance Imaging. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068982