Enhanced Critical Size Defect Repair in Rabbit Mandible by Electrospun Gelatinβ-TCP Composite Nanofibrous Membranes
Joint Authors
Bing, Han
Zhang, Xuehui
Meng, Song
Dai, Xiaohan
Xu, Mingming
Liang, Xu-Deng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The design and fabrication of biodegradable barrier membranes with satisfactory structure and composition remain a considerable challenge for periodontal tissue regeneration.
We have developed a biomimetic nanofibrous membrane made from a composite of gelatin and β-tricalcium phosphate (β-TCP).
We previously confirmed the in vitro biological performance of the membrane material, but the efficacy of the membranes in promoting bone repair in situ has not yet been examined.
Gelatin/β-TCP composite nanofibers were fabricated by incorporation of 20 wt.% β-TCP nanoparticles into electrospun gelatin nanofibers.
Electron microscopy showed that the composite membranes presented a nonwoven structure with an interconnected porous network and had a rough surface due to the β-TCP nanoparticles, which were distributed widely and uniformly throughout the gelatin-fiber matrix.
The repair efficacy of rabbit mandible defects implanted with bone substitute (Bio-Oss) and covered with the gelatin/β-TCP composite nanofibrous membrane was evaluated in comparison with pure gelatin nanofibrous membrane.
Gross observation, histological examination, and immunohistochemical analysis showed that new bone formation and defect closure were significantly enhanced by the composite membranes compared to the pure gelatin ones.
From these results, we conclude that nanofibrous gelatin/β-TCP composite membranes could serve as effective barrier membranes for guided tissue regeneration.
American Psychological Association (APA)
Xu, Mingming& Zhang, Xuehui& Meng, Song& Dai, Xiaohan& Bing, Han& Liang, Xu-Deng. 2015. Enhanced Critical Size Defect Repair in Rabbit Mandible by Electrospun Gelatinβ-TCP Composite Nanofibrous Membranes. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068985
Modern Language Association (MLA)
Xu, Mingming…[et al.]. Enhanced Critical Size Defect Repair in Rabbit Mandible by Electrospun Gelatinβ-TCP Composite Nanofibrous Membranes. Journal of Nanomaterials No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068985
American Medical Association (AMA)
Xu, Mingming& Zhang, Xuehui& Meng, Song& Dai, Xiaohan& Bing, Han& Liang, Xu-Deng. Enhanced Critical Size Defect Repair in Rabbit Mandible by Electrospun Gelatinβ-TCP Composite Nanofibrous Membranes. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068985