Inhibitory Effect Evaluation of Glycerol-Iron Oxide Thin Films on Methicillin-Resistant Staphylococcus aureus

Abstract EN

The main purpose of this study was to evaluate the inhibitory effect of glycerol- iron oxide thin films on Methicillin-Resistant Staphylococcus aureus (MRSA).

Our results suggest that glycerol-iron oxide thin films could be used in the future for various biomedical and pharmaceutical applications.

The glycerol-iron oxide thin films have been deposited by spin coating method on a silicon (111) substrate.

The structural properties have been studied by X-ray diffraction (XRD) and scanning electron spectroscopy (SEM).

The XRD investigations of the prepared thin films demonstrate that the crystal structure of glycerol-iron oxide nanoparticles was not changed after spin coating deposition.

On the other hand, the SEM micrographs suggest that the size of the glycerol-iron oxide microspheres increased with the increase of glycerol exhibiting narrow size distributions.

The qualitative depth profile of glycerol-iron oxide thin films was identified by glow discharge optical emission spectroscopy (GDOES).

The GDOES spectra revealed the presence of the main elements: Fe, O, C, H, and Si.

The antimicrobial activity of glycerol-iron oxide thin films was evaluated by measuring the zone of inhibition.

After 18 hours of incubation at 37°C, the diameters of the zones of complete inhibition have been measured obtaining values around 25 mm.