Application of Gold Nanoparticles of Different Concentrations to Improve the Therapeutic Potential of Autologous Conditioned Serum: Potential Implications for Equine Regenerative Medicine
Joint Authors
Grzesiak, Jakub
Kolankowski, Jakub
Hecold, Mateusz
Rac, Olga
Teterycz, Helena
Marycz, Krzysztof
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this work was to evaluate the effect of different concentrations of gold nanoparticles (AuNPS) on equine platelet morphology, ultrastructure as well as secretion of bone morphogenetic protein 2 (BMP-2), vascular endothelial growth factor (VEGF), gelsolin (GSN), and tumor necrosis factor alpha (TNF-α).
The gold nanoparticles, with an average diameter of 20 nm, were incubated with whole anticoagulated blood at 1%, 5%, and 10% w/v for 24 hours.
We showed that the application of gold nanoparticles at all the tested concentrations led to platelet activation; however, 5% of AuNPS resulted in the secretion of elevated levels of GSN and VEGF, while the concentration of TNF-α was the lowest.
The data indicate that this method may be considered a promising tool for improving the currently used in clinical practice commercially available autologous conditioned serum (ACS) isolation systems for the treatment of equine osteoarthritis.
American Psychological Association (APA)
Marycz, Krzysztof& Kolankowski, Jakub& Grzesiak, Jakub& Hecold, Mateusz& Rac, Olga& Teterycz, Helena. 2015. Application of Gold Nanoparticles of Different Concentrations to Improve the Therapeutic Potential of Autologous Conditioned Serum: Potential Implications for Equine Regenerative Medicine. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1069086
Modern Language Association (MLA)
Marycz, Krzysztof…[et al.]. Application of Gold Nanoparticles of Different Concentrations to Improve the Therapeutic Potential of Autologous Conditioned Serum: Potential Implications for Equine Regenerative Medicine. Journal of Nanomaterials No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1069086
American Medical Association (AMA)
Marycz, Krzysztof& Kolankowski, Jakub& Grzesiak, Jakub& Hecold, Mateusz& Rac, Olga& Teterycz, Helena. Application of Gold Nanoparticles of Different Concentrations to Improve the Therapeutic Potential of Autologous Conditioned Serum: Potential Implications for Equine Regenerative Medicine. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1069086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069086