Sythesis, Modification, and Biosensing Characteristics of Au2SAuAgS-Coated Gold Nanorods

Abstract EN

The Au2S/AuAgS-coated gold nanorods (Au2S/AuAgS/GNRs) are prepared by a facile synthesis method and functionally modified for their biosensing application.

In the preparation process, the longitudinal plasmon resonance (LPR) bands of Au2S/AuAgS/GNRs can be changed by controlling the thickness of the chalcogenide layer coated on GNRs.

Especially, the LPR band located at 800 nm is obtained for biosensing application in the near-infrared region.

Furthermore, mercaptoundecanoic acid (MUA) and poly(styrenesulfonate) (PSS) are, respectively, used to modify Au2S/AuAgS/GNRs to acquire the functional nanoprobes; that is, MUA-modified and PSS-modified Au2S/AuAgS/GNRs and their different chemical reaction mechanisms are studied by the absorption spectrum and ξ-potential measurement.

Then, the functional nanoprobes are incubated with anti-prostate-specific antigen (PSA) antibody to detect PSA.

The experimental results demonstrate that the functional nanoprobes are sensitive to the target binding of PSA.

Therefore, Au2S/AuAgS/GNRs are suitable to form the bioprobes for detection of PSA in early-phase prostate cancer.