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The Comparative PDT Experiment of the Inactivation of HL60 on Modified TiO2 Nanoparticles
Joint Authors
Xiong, Jianwen
Chen, Li
Ai, Bao-Quan
Lu, Kaiqi
He, Qiyun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Four samples of modified titanium dioxide (TiO2), Fe/TiO2 (2 wt%), Fe/TiO2 (5 wt%), and 5-ALA/TiO2, were experimented in photodynamic therapy (PDT) on leukemia cells HL60, performing promising photocatalytic inactivation effect.
Fe/TiO2 and 5-ALA/TiO2 were synthesized in methods of precipitation and ultrasonic methods, respectively.
X-ray diffraction spectra and UV-Vis spectra were studied for the samples’ crystalline phase and redshift of absorption peak.
Further, FTIR spectra and Raman spectra were obtained to examine the combination of 5-aminolevulinic (5-ALA) and TiO2 nanoparticles.
The toxicity of these four kinds of nanoparticles was studied through darkroom experiments.
And based on the concentration which caused the same toxic effect (90%) on HL60, PDT experiments of TiO2, Fe/TiO2 (2%), Fe/TiO2 (5%), and ALA/TiO2 were done, resulting in the fact that the photokilling efficiency was 69.7%, 71.6%, 72%, and 80.6%, respectively.
Scanning electron microscope (SEM) images of the samples were also taken to study the morphology of HL60 cells before and after PDT, resulting in the fact the activation of the modified TiO2 from PDT was the main cause of cell apoptosis.
American Psychological Association (APA)
Lu, Kaiqi& He, Qiyun& Chen, Li& Ai, Bao-Quan& Xiong, Jianwen. 2015. The Comparative PDT Experiment of the Inactivation of HL60 on Modified TiO2 Nanoparticles. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069111
Modern Language Association (MLA)
Lu, Kaiqi…[et al.]. The Comparative PDT Experiment of the Inactivation of HL60 on Modified TiO2 Nanoparticles. Journal of Nanomaterials No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069111
American Medical Association (AMA)
Lu, Kaiqi& He, Qiyun& Chen, Li& Ai, Bao-Quan& Xiong, Jianwen. The Comparative PDT Experiment of the Inactivation of HL60 on Modified TiO2 Nanoparticles. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069111